Exonic sequencing identifies TLR1 genetic variation associated with mortality in Thais with melioidosis

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Common TLR1 Genetic Variation Is Not Associated with Death from Melioidosis, a Common Cause of Sepsis in Rural Thailand

Melioidosis, infection caused by the Gram-negative bacterium Burkholderia pseudomallei, is a common cause of sepsis in northeast Thailand. In white North Americans, common functional genetic variation in TLR1 is associated with organ failure and death from sepsis. We hypothesized that TLR1 variants would be associated with outcomes in Thais with melioidosis. We collated the global frequencies o...

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ژورنال

عنوان ژورنال: Emerging Microbes & Infections

سال: 2019

ISSN: 2222-1751

DOI: 10.1080/22221751.2019.1575172